Chromaticity dependence of the transverse effective impedance in the CERN Proton Synchrotron

The current knowledge of the transverse beam coupling impedance of the CERN Proton Synchrotron (PS) has been established with beam-based measurements at different energies. The transverse coherent tune shift as a function of the beam intensity has been measured in order to evaluate the total effective imaginary part of the transverse impedance in the accelerator at the energies of 7, 13 and 25 GeV. Measurements have been performed changing the vertical chromaticity for each vertical tune scan with intensity. The data analysis revealed an increase of impedance with chromaticity for all the considered energies. The transverse impedance can be compared with the previously evaluated theoretical impedance budget taking into account the individual contribution of several machine devices

When and where do you want to hide? Recommendation of location privacy preferences with local differential privacy

In recent years, it has become easy to obtain location information quite precisely. However, the acquisition of such information has risks such as individual identification and leakage of sensitive information, so it is necessary to protect the privacy of location information. For this purpose, people should know their location privacy preferences, that is, whether or not he/she can release location information at each place and time. However, it is not easy for each user to make such decisions and it is troublesome to set the privacy preference at each time. Therefore, we propose a method to recommend location privacy preferences for decision making. Comparing to existing method, our method can improve the accuracy of recommendation by using matrix factorization and preserve privacy strictly by local differential privacy, whereas the existing method does not achieve formal privacy guarantee. In addition, we found the best granularity of a location privacy preference, that is, how to express the information in location privacy protection. To evaluate and verify the utility of our method, we have integrated two existing datasets to create a rich information in term of user number. From the results of the evaluation using this dataset, we confirmed that our method can predict location privacy preferences accurately and that it provides a suitable method to define the location privacy preference

Phytochemical analysis and antioxidant activity of Haloxylon salicarnicum, Ochradenus arabicus and Tamarix nilotica

In the present investigation, the preliminary phytochemical analysis and antioxidant potential of hexane, chloroform, acetone and methanol extracts of Haloxylon salicarnicum, Ochradenus arabicus and Tamarix nilotica were reported. The presence of flavonoid, alkaloid, phenols, terpenoids, carbohydrate, tannin, protein, steroids, saponin, phlobatannin, cardiacglycoside, anthraquinines and volatile oils were determined and for antioxidant activity, DPPH, ABTS, superoxide anion radical and hydroxyl radical scavenging potential were studied. Strong presence of alkaloid, tannin, steroids in H. salicarnicum, flavonoid and phenols in O. arabicus and saponin T. nilotica were observed. In the present investigation, all the extracts inhibited the free radicals the methanol extract of O. arabicus was identified as potential crude extract compared to all other extracts with the IC50 values of 91.65 (DPPH), 94.62 (ABTS), 95.82 (O2) and 96.02 (OH) µg/mL. Whereas, the IC50 value of the standard, Gallic acid were 125.25 (DPPH), 142.32 (ABTS), 130.78 (O2) and 139.93 µg/mL (OH). Whereas, the IC50 value of the standard, Gallic acid were 125.25 (DPPH), 142.32 (ABTS), 130.78 (O2) and 139.93 µg/mL (OH)The present study suggests that methanol extract of O. arabicus can be used for the isolation potential natural antioxidant

LHC Impedance Model: Experience with High Intensity Operation in the LHC

The CERN Large Hadron Collider (LHC) is now in luminosity production mode and has been pushing its performance in the past months by increasing the proton beam brightness, the collision energy and the machine availability. As a consequence, collective effects have started to become more and more visible and have effectively slowed down the performance increase of the machine. Among these collective effects, the interaction of brighter LHC bunches with the longitudinal and transverse impedance of the machine has been observed to generate beam induced heating, as well as longitudinal and transverse instabilities since 2010. This contribution reviews the current LHC impedance model obtained from theory, simulations and bench measurements as well as a selection of measured effects with the LHC beam

A Sex-Specific Metabolite Identified in a Marine Invertebrate Utilizing Phosphorus-31 Nuclear Magnetic Resonance

Hormone level differences are generally accepted as the primary cause for sexual dimorphism in animal and human development. Levels of low molecular weight metabolites also differ between men and women in circulating amino acids, lipids and carbohydrates and within brain tissue. While investigating the metabolism of blue crab tissues using Phosphorus-31 Nuclear Magnetic Resonance, we discovered that only the male blue crab (Callinectes sapidus) contained a phosphorus compound with a chemical shift well separated from the expected phosphate compounds. Spectra obtained from male gills were readily differentiated from female gill spectra. Analysis from six years of data from male and female crabs documented that the sex-specificity of this metabolite was normal for this species. Microscopic analysis of male and female gills found no differences in their gill anatomy or the presence of parasites or bacteria that might produce this phosphorus compound. Analysis of a rare gynandromorph blue crab (laterally, half male and half female) proved that this sex-specificity was an intrinsic biochemical process and was not caused by any variations in the diet or habitat of male versus female crabs. The existence of a sex-specific metabolite is a previously unrecognized, but potentially significant biochemical phenomenon. An entire enzyme system has been synthesized and activated only in one sex. Unless blue crabs are a unique species, sex-specific metabolites are likely to be present in other animals. Would the presence or absence of a sex-specific metabolite affect an animal's development, anatomy and biochemistry

Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response

Hypoxia in solid tumors is associated with treatment resistance, resulting in poor prognosis. Tribbles homolog 3 (TRIB3) is induced during hypoxia and is involved in multiple cellular pathways involved in cell survival. Here, we investigated the role of TRIB3 in breast cancer. TRIB3 mRNA expression was measured in breast tumor tissue from 247 patients and correlated with clinicopathological parameters and clinical outcome. Furthermore, we studied TRIB3 expression regulation in cell lines, xenografts tissues and human breast cancer material using Reverse transcriptase, quantitative polymerase chain reaction (RT-qPCR) and immunohistochemical staining. Finally, the effect of small interfering RNA (siRNA) mediated TRIB3 knockdown on hypoxia tolerance was assessed. Breast cancer patients with low, intermediate or high TRIB3 expression exhibited a mean disease free survival (DFS) of 80 (95% confidence interval [CI] = 74 to 86), 74 (CI = 67 to 81), and 63 (CI = 55 to 71) months respectively (P = .002, Mantel-Cox log-rank). The prognostic value of TRIB3 was limited to those patients that had received radiotherapy as part of their primary treatment (n = 179, P = .005) and remained statistically significant after correction for other clinicopathological parameters (DFS, Hazard Ratio = 1.90, CI = 1.17 to 3.08, P = .009). In breast cell lines TRIB3 expression was induced by hypoxia, nutrient starvation, and endoplasmic reticulum stress in an hypoxia inducible factor 1 (HIF-1) independent manner. TRIB3 induction after hypoxia did not increase with decreasing oxygen levels. In breast tumor xenografts and human breast cancer tissues TRIB3 co-localized with the hypoxic cell marker pimonidazole. The induction of TRIB3 by hypoxia was shown to be regulated via the PERK/ATF4/CHOP pathway of the unfolded protein response and knockdown of TRIB3 resulted in a dose-dependent increase in hypoxia sensitivity. TRIB3 is independently associated with poor prognosis of breast cancer patients, possibly through its association with tumor cell hypoxi